This trial is unknown!
Search for a recruiting clinical trial for your condition
Your journey
1What's a trial
2Find
3Review
4Get in touch
More info
You can access this
clinical trial
if you have
Catheter-Related Infections or Bacteremia.
and you are
over 18
years old
4
The primary goal of this phase is to monitor the long-term effects.
The treatment is already on the market.
Show me locations

The purpose

The antibiotic lock technique (ALT) is used as local treatment for Catheter-Related Bacteremia (CRB). It consists in the administration of a concentrated antimicrobial solution with a calculated volume to fill the lumen of the catheter. The lock solution is indwelled within the catheter for a defined period of hours or days before been removed. Currently, the Infectious Diseases Society of America (IDSA) Guidelines for treatment and management of CRB, recommends to change the antibiotic solution every 24 hours. The investigators expect to determine the stability of the concentration of vancomycin, teicoplanin, linezolid, daptomycin and tigecycline used in lock solutions, and thus to assay the optimal timeframe that the concentration of antibiotic used in lock solution keeps its in vivo antimicrobial activity. Study Hypothesis: An antibiotic lock solution maintains in vivo concentration and antimicrobial activity for at least 10 days after its infusion inside a subcutaneous port catheter.

Provided treatments

  • Drug: Vancomycin antimicrobial-lock solution
  • Drug: Teicoplanin antimicrobial-lock solution
  • Drug: Linezolid antimicrobial-lock solution
  • Drug: Daptomycin antimicrobial-lock solution
  • Drug: Tigecycline antimicrobial-lock solution

Locations near you

Unfortunately, there are no recruiting locations near you. Please check the list with all locations below.
Tris trial is registered with FDA with number: NCT01592032. The sponsor of the trial is Clinica Universidad de Navarra, Universidad de Navarra and it is looking for 125 volunteers for the current phase.
Official trial title:
Concentration and Antibiotic Activity in Antibiotic Lock Solutions