The antibiotic lock technique (ALT) is used as local treatment for Catheter-Related
Bacteremia (CRB). It consists in the administration of a concentrated antimicrobial solution
with a calculated volume to fill the lumen of the catheter. The lock solution is indwelled
within the catheter for a defined period of hours or days before been removed.
Currently, the Infectious Diseases Society of America (IDSA) Guidelines for treatment and
management of CRB, recommends to change the antibiotic solution every 24 hours.
The investigators expect to determine the stability of the concentration of vancomycin,
teicoplanin, linezolid, daptomycin and tigecycline used in lock solutions, and thus to assay
the optimal timeframe that the concentration of antibiotic used in lock solution keeps its in
vivo antimicrobial activity.
Study Hypothesis: An antibiotic lock solution maintains in vivo concentration and
antimicrobial activity for at least 10 days after its infusion inside a subcutaneous port