The use of combined oral contraceptives has been associated with increased risk of adverse
cardiovascular events. The exact mechanism by which these drugs exert this influence is
uncertain. It is possible that changes in autonomic nervous system are involved. The
objective of these study was to evaluate the effect of the use of a contraceptive containing
20 mcg of ethinyl estradiol and 3mg of drospirenone in the autonomic nervous system in
healthy women. Few studies have been conducted in the field of hormonal contraception and
evaluation of the autonomic nervous system work and no prospective, controlled study was
published so far. These study will be the first.