The Principle objective of this study is To evaluate the performance of NRA, NRA-p and REMA-p
for the detection of M. tuberculosis complex from sputum samples from adult pulmonary TB
suspects in a high TB and HIV prevalence setting, using LJ and MGIT culture as gold standard.
The Secondary objectives are:
- To measure the performance of each assay (NRA, NRA-p, REMA-p) in sputum smear-negative
- To describe the results of the colorimetric methods in HIV-positive and HIV-negative
- To assess the time to detection of both NRA/NRA-p, REMA-p methods.
- To evaluate the feasibility of the NRA, NRA-p, REMA-p methods.
- To determine the rate of contamination of the NRA, NRA-p and REMA-p assays.
- To evaluate the proportion and the clinical relevance of NTM among TB suspects in a high
TB and HIV prevalence setting.
- To provide capacity building for TB diagnosis in Mbarara.