Study summary: "Liver transplantation and the reticuloendothelial clearance capacity."
The purpose of this study is to evaluate the effect of liver transplantation on the immune
This study will involve the taking of a number of observations but does not involve any
treatment, which differs from normal care. Indications for transplantation are solely based
on the best clinical practice, which is usually performed at the department.
The study measures liver function based on the clearance of different "marker" substances by
the liver. These substances are given intravenously and their clearance will be measured from
All substances used in this study are registered in the United Kingdom for clinical
applications and already used in clinical practice over years. They are safe and without any
risk to harm individuals under study. Furthermore no side effects or any symptoms caused by
the administration of these substances are expected.
Measurements of liver function are undertaken before transplantation, 1 and 7 days following
the transplant. There is no restriction from any of the patient's prescribed medication. All
blood samples will be removed from the cannula (drip) and will not require repeated
injections. It is hoped that this research will lead to a greater understanding of the
effects of liver transplantation on the immune system.