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Effect of Remote Ischemic Preconditioning on Brain Injury in Carotid Endarterectomy (NCT03027011)

This is a randomized controlled trial designed to test an intervention (Remote ischemic preconditioning) in patients undergoing carotid endarterectomy (CEA).Remote ischemic preconditioning(RIPC) with transient upper limb ischemia/reperfusion is a novel, simple, cost-free,non-pharmacological and non-invasive strategy.The purpose of this study is to evaluate the effects of Remote Ischaemic Preconditioning on perioperative ischaemic injury in patients undergoing carotid endarterectomy compared to control intervention.The outcomes of interest include neurocognitive function,clinical outcomes,and biomarkers of brain injury.
  • Procedure: Remote Ischemic Preconditioning
    RIPC will be induced during anesthesia by 3 cycles of 5-min upper limb ischemia and 5-min reperfusion using a blood-pressure cuff inflated to a pressure 200mmHg
    • RIPC
  • Procedure: Control
    Control group without remote ischemic preconditioning
    Ages eligible for Study
    55 Years to 80 Years
    Genders eligible for Study
    All
    Accepts Healthy Volunteers
    No
    Inclusion Criteria:
    • Patients undergoing carotid endarterectomy
    • Patients aged 55 years to 80 years
    Exclusion Criteria:
    • Inability to give informed consent
    • Known Deep venous thrombosis (DVT) in arm
    • Pre-existing lymphedema or axillary node dissection both arms
    • Arteriovenous fistula or graft in both arms
    • Left ventricular ejection fraction less than 50%
    • Diagnosis of dementia, intellectual disability, or mental illness including depression, anxiety, or schizophrenia
    Remote ischemic preconditioning (RIPC) protocol will be induced during anesthesia by 3 cycles of 5-min upper limb ischemia and 5-min reperfusion using a blood pressure cuff inflated to a pressure 200mmHg

    1 locations

    China (1)
    • The Affiliated Hospital of Xuzhou Medical University
      recruiting
      Xuzhou, Jiangsu, China, 221000
    Status:
    recruiting
    Type:
    Interventional
    Phase:
    -
    Start:
    28 February, 2017
    Updated:
    08 March, 2017
    Participants:
    40
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