• Overview
  • Eligibility
  • More info
  • Locations

MRI Screening of Second Primary Cancer Occurring Within Radiation Fields After Treatment by External Beam Radiation Therapy for Hereditary Retinoblastoma (NCT03026998)

The purpose of this study is to assess the benefit of MR screening for asymptomatic head & neck (or CNS) second primary cancers occurring in hereditary retinoblastoma patients previously treated by external beam radiation therapy (EBRT).
  • Procedure: MRI
    MRI will be performed each year during 10 years.
    Ages eligible for Study
    7 Years to 35 Years
    Genders eligible for Study
    All
    Accepts Healthy Volunteers
    No
    Inclusion Criteria:
    • Personal history of hereditary retinoblastoma (i.e., familial history of retinoblastoma, or bilateral retinoblastoma, or unilateral multifocal retinoblastoma, or identified germline RB1 mutation or 13q deletion)
    • External beam radiation therapy (EBRT) used for retinoblastoma treatment
    • Age at inclusion between 7 and 35 years
    • Time period between the end of EBRT and inclusion date of 5 years or more
    • Written informed consent signed by patient (or legal representative)
    Exclusion Criteria:
    • Personal history of non-familial unilateral unifocal retinoblastoma without RB1 germline mutation.
    • Personal history of second primary neoplasm occurring within radiation fields
    • Contraindication for MRI (pacemaker, intraocular metallic foreign body, defibrillators or other implanted electronic devices, intracranial ferro-magnetic clips) or associated conditions preventing from MR examination (intraocular prostheses and implants are not a contraindication for MRI; orthodontic metallic devices are not a contraindication but might decrease the image quality and should be removed, if possible)
    • Patients unable to comply with follow-up study requirements, for any geographical, social or psychological reason
    Patients with hereditary retinoblastoma treated during infancy by external beam radiation therapy (EBRT) the risk of second primary cancer occurring within radiation fields is high. The aim of this study is to depict by MRI secondary tumors as early as possible, before the occurrence of clinical symptoms. Affected patients will be further managed in a national expert center with dedicated diagnostic and treatment procedures. However, the benefit of such management has to be assessed in terms of prognosis.

    1 locations

    France (1)
    • Institut Curie
      recruiting
      Paris, France, 75005
    Status:
    recruiting
    Type:
    Interventional
    Phase:
    -
    Start:
    18 March, 2017
    Updated:
    09 July, 2017
    Participants:
    190
    Apply
    A girl giving information about available additional trials.

    FindMeCure helps you find, understand and join clinical trials from all over the world.

    There are more clinical trials for your condition!