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Influence of Erythromycin on ad Libitum Food Intake and the Evaluation of Motilin in Food Timing in Healthy Volunteers and Patients (NCT03024879)

In this study, the investigators aimed at evaluating the role of motilin in the regulation of food intake. Motilin, a gastrointestinal hormone, is a hunger signal in healthy volunteers and is significantly increased in obese patients. Its role in food intake regulation might contribute to the pathogenesis of obesity.
  • Drug: Erythromycin
    • Drug: Saline
      Ages eligible for Study
      18 Years to 60 Years
      Genders eligible for Study
      All
      Accepts Healthy Volunteers
      Accepts Healthy Volunteers
      Inclusion Criteria:
      • BMI < 30 kg/m² for lean volunteers
      • BMI > 30 kg/m² for obese volunteers
      • Subject is capable and willing to give informed consent
      • Female volunteers of child bearing potential must use oral, injected or implanted hormonal methods of contraception
      Exclusion Criteria:
      • Female volunteer is pregnant or breastfeeding
      • GI diseases, major abdominal surgery
      • Major psychiatric illnesses
      • Volunteers that use drugs affecting the GI tract or the central nervous system
      • Volunteers suffering from endocrine diseases such as diabetes, Cushing's disease, Addison's disease, hypothalamic tumor
      • Volunteers that have undergone surgical procedure for weight loss
      Status:
      enrolling by invitation
      Type:
      Interventional
      Phase:
      Start:
      28 February, 2014
      Updated:
      15 January, 2017
      Participants:
      15
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