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The Effect of Sevoflurane or Propofol on Brain Injury and Neurocognitive in Pediatric Living Related Liver Transplantation (NCT03024840)

To study the effect of different anaesthetic methods on pediatric neurocognitive development and cerebral injury during pediatric living related liver transplantation .
  • Drug: Sevoflurane
    Sevoflurane: 1%~2%
    • Drug: Propofol
      Propofol: 9-15 mg/kg/h
      Ages eligible for Study
      4 Months to 12 Months
      Genders eligible for Study
      All
      Accepts Healthy Volunteers
      No
      Inclusion Criteria:
      • Children with end-stage liver disease Children with biliary atresia
      Exclusion Criteria:
      • pre-existing cerebral disease second liver transplantation
      Since the 1960 s, with the successful development of liver transplantation, it has become an important method for the treatment of patients with end-stage liver disease.Biliary atresia1 is the most frequent causes of pediatric end-stage liver disease,.The morbidity of congenital biliary atresia is 1/8000-18, 0002 ,which influence the patients' overall growth and development situation. The rising of living donor liver transplantation has provide children with the chance of a timely treatment since the 1980 s, It is no doubt that pediatric liver transplantation is facing with many complications, including the most importance of neurocognitive development .Now the researches of neurological complications is less .According to statistics, the incidence of neurological complications after pediatric liver transplantation was 8% - 46% . So it is necessary to research the neurological complications and brain protection strategy .Previous studies have studied that some anaesthetic have uncertain affect on the development of children.

      1 locations

      China (1)
      • No.24 Fukang Road,Nankai District
        Tianjin, Tianjin, China, 300192
      Status:
      enrolling by invitation
      Type:
      Interventional
      Phase:
      -
      Start:
      30 November, 2016
      Updated:
      14 January, 2017
      Participants:
      60
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