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Identification of Protein Markers of Vitality in Skin Wounds by Forensic Multiplex Analysis (NCT02898636)

Identify the cytokine or combination of cytokines, with the best diagnostic performance to characterize the vital nature of a skin wound in the body.
  • Other: autopsy
    At autopsy achieving adequate sampling of lesions and healthy skin
    Ages eligible for Study
    18 Years to 100 Years
    Genders eligible for Study
    All
    Accepts Healthy Volunteers
    No
    Inclusion Criteria:
    • Adult died 18 years or more
    • Having at least one recent ante-mortem skin wound (occurring less than 4 hours prior to death)
    • Hours of death and the establishment of the ante-mortem wound known (date, hours and minutes)
    Exclusion Criteria:
    • Immunocompromised patients (HIV infection, immunosuppressive therapy ...)
    • Putrefaction signs (abdominal patch of green ...)
    Determining the vitality of skin wounds, that is to say their antemortem character, is an important issue in forensic pathology. The only criterion vitality currently recognized (but whose diagnostic performance remains limited) is the microscopic demonstration of an inflammatory infiltrate of neutrophils. The search for more reliable diagnostic biomarkers is required. By their early expression of the injury site, inflammatory cytokines are potential candidates and their quantification in injured skin could optimize the diagnosis of vitality injury.

    The objective is to identify the cytokine or combination of cytokines, with the best diagnostic performance to characterize the vital nature of a skin wound in the body.

    1 locations

    France (1)
    • PEYRON
      recruiting
      Montpellier, France, 34295
    Status:
    recruiting
    Type:
    Observational
    Phase:
    -
    Start:
    31 August, 2016
    Updated:
    07 September, 2016
    Participants:
    50
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