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A Multiple-Dose, Dose-Escalation Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of LY3041658 in Patients With Skin Diseases (NCT02896868)

The main purpose of this study is to investigate the safety and tolerability of the study drug known as LY3041658 in participants with certain types of skin diseases. The study will measure how the body absorbs, breaks down and gets rid of LY3041658. It will last about 127 days for each participant, not including screening. This study is for research purposes only, and is not intended to treat any medical condition.
  • Drug: LY3041658
    Administered IV.
    • Drug: Placebo
      Administered IV.
      Ages eligible for Study
      18 Years and older
      Genders eligible for Study
      All
      Accepts Healthy Volunteers
      No
      Inclusion Criteria:
      • Investigator confirmed diagnosis of certain skin diseases for at least 6 months.
      • Active skin lesions that are not responding to standard therapies.
      • Willing to undergo pre- and post-treatment skin biopsies of lesions.
      Exclusion Criteria:
      • Have other skin diseases that may interfere with evaluation of the specified skin disease being studied.

      5 locations

      United States (5)
      • Parexel Early Phase Unit at Glendale
        not yet recruiting
        Glendale, California, United States, 91206
      • Dawes Fretzin Clinical Research
        recruiting
        Indianapolis, Indiana, United States, 46256
      • PAREXEL-Phase 1 Baltimore Harbor Hospital Center
        recruiting
        Baltimore, Maryland, United States, 21225
      • Duke University
        recruiting
        Durham, North Carolina, United States, 27710
      • Altoona Center for Clinical Research
        recruiting
        Duncansville, Pennsylvania, United States, 16635
      Status:
      recruiting
      Type:
      Interventional
      Phase:
      Start:
      07 November, 2016
      Updated:
      31 August, 2017
      Participants:
      60
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