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Neuronal Excitability of Hyperpolarization-activated Cyclic Nucleotide-gated (HCN1) Channel Mutations in Dravet Syndrome (NCT02896608)

This study addresses the changes in the axonal excitability parameters. It will compare these changes in patients with early infantile epileptic encephalopathy with HCN1 channel mutation and in control patients, with and without epilepsy.
  • Device: measure of neuronal excitability
    Ages eligible for Study
    15 Years and older
    Genders eligible for Study
    All
    Accepts Healthy Volunteers
    Accepts Healthy Volunteers
    Inclusion Criteria:
    • early infantile epileptic encephalopathy with HCN1 channel mutation
    • control patients with no neurologic pathology (age, gender and body temperature matched)
    • epileptic patients (age, gender and body temperature matched)
    Exclusion Criteria:
    • pregnant or breast feeding patient

    1 locations

    France (1)
    • Fondation Ophtalmologique Adolphe de Rothschild
      recruiting
      Paris, France, 75019
    Status:
    recruiting
    Type:
    Observational
    Phase:
    -
    Start:
    30 September, 2015
    Updated:
    02 February, 2017
    Participants:
    45
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