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Osteoarticular Tumor Characterization by Advanced Imaging (NCT02895633)

The purpose is to compare and evaluate multiple functional imaging methods (perfusion, diffusion, spectroscopy) for initial benign/malignant characterization of osteoarticular tumors and to determine which method or which association of methods could improve non invasive tissue characterization. Secondary purposes are: - to determine a possible correlation between some parameters and the histological grade (FNCLCC) - to suggest a coherent diagnostic imaging approach for osteoarticular tumors. The ancillary study will enroll patients needing radiological tumor follow-up. The purpose is to identify tools for evaluation of tumor activity and therapeutic response before modification of morpho-volumetric data.
  • Other: Ecography
    Standard Doppler ultrasound and perfusion imaging after injection of Sonovue
    • Other: CT scan
      With injection of Iomeron 400
      • Other: MRI
        With injection of gadolinium (Multihance)
        Ages eligible for Study
        18 Years and older
        Genders eligible for Study
        All
        Accepts Healthy Volunteers
        No
        Inclusion Criteria:
        • patients examined for initial assessment of bone or peripheral soft-tissue primitive tumor
        • patients with normal awareness level
        • patients having signed informed consent
        Exclusion Criteria:
        • pregnant women
        • persons deprived of liberty
        • persons under legal protection or unable to give informed consent
        • persons in life-threatening emergency
        • allergy to Sonovue, iodinated contrast media or gadolinium chelates
        • risk of pregnancy
        • breastfeeding women
        • acute coronary syndrome or unstable ischemic cardiopathy (ban on injection of contrast agent for CT scan)
        • renal failure (ban on injection of contrast agent for MRI and CT scan)
        • contraindication to MRI
        Patients refered for the initial evaluation of suspected osteoarticular masses will be included in this study after signing an informed consent.

        Histologic analysis will be used as a gold standard.

        The following imaging techniques will be evaluated:

        - contrast enhanced ultrasonography

        - Low dose CT perfusion

        - Magnetic resonance perfusion

        - Diffusion weighted imaging

        - Magnetic resonance proton spectroscopy

        1 locations

        France (1)
        • Service d'Imagerie Guilloz, CHRU Nancy
          recruiting
          Nancy, France
        Status:
        recruiting
        Type:
        Interventional
        Phase:
        -
        Start:
        31 October, 2009
        Updated:
        04 September, 2016
        Participants:
        1090
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