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Prehabilitation for Adults With End Stage Renal Disease on the Kidney Transplant Waitlist (NCT02895243)

This pilot study will be a clinical trial to test the feasibility and effectiveness of a kidney transplant (KT) prehabilitation intervention in adults with end stage renal disease (ESRD) who are within 3-6 months of transplantation.
  • Other: Prehabilitation
    The study will use a generic prehabilitation program which will include the following components: Warm-up, cardiovascular training, strength training, flexibility training, and cool down. Prehabilitation will occur once per week and approximately 1 hour in duration. Participants will take part in prehabilitation until they receive a kidney transplant which by study design is approximately for 3-6 months.
    • exercise training
Ages eligible for Study
18 Years and older
Genders eligible for Study
All
Accepts Healthy Volunteers
No
Inclusion Criteria:
  • Men and women with end stage renal disease who are within 3-6 months of kidney transplantation and are on the kidney transplant waitlist at Johns Hopkins
  • Must be at least 18 years or older at enrollment
  • Must be English speaking
  • Must be enrolled in an ongoing cohort study of adults with ESRD who are being evaluated for kidney transplantation
  • Must be willing to participate in a prehabilitation program and able to give informed consent
Exclusion Criteria:
  • Patients who have any of the following medical conditions will be excluded from the study:
  • Active Angina pectoris
  • Chronic lung disease and daily use of oxygen
  • Cerebral vascular disease
  • Musculoskeletal conditions that would limit participation in prehabilitation
  • Lower- or upper-extremity amputation
  • Orthopedic disorders exacerbated by physical activity
  • Decreased mental capacity
  • Patients who live outside of Maryland will not be included in the study.
Prehabilitation is the enhancement of functional capacity of a patient to improve their ability to withstand a future stressor. The investigators primary objective is to demonstrate feasibility for prehabilitation in Aim 1 and test whether the number of prehabilitation sessions is associated with increased physical activity. The investigators will formally test whether prehabilitation is associated with a reduction in short term and long term KT outcomes as part of Aim 2. The investigators will test whether there is an effect of prehabilitation on short-term (KT length of stay> 2 weeks, early hospital readmission and delayed graft function) and long-term (acute rejection (within the first year), 1 year patient and graft survival) outcomes compared to standard of care controls. Participants will be followed for 3-6 months or until they receive a kidney transplant.

1 locations

United States (1)
  • Johns Hopkins Physical Medicine and Rehabilitation
    Not specified
    Lutherville, Maryland, United States, 21093
Status:
enrolling by invitation
Type:
Interventional
Phase:
-
Start:
31 May, 2016
Updated:
05 September, 2016
Participants:
90
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