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A Phase II Pilot Study of Stereotactic Radiosurgery for Limited Malignant Melanoma Brain Metastases (NCT00003911)

National Cancer Institute (NCI)
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Stereotactic radiosurgery may kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of radiation therapy followed by stereotactic radiosurgery in treating patients who have brain metastases from malignant melanoma.
  • Radiation: stereotactic radiosurgery
    Ages eligible for Study
    all
    Genders eligible for Study
    All
    Accepts Healthy Volunteers
    No
    OBJECTIVES: I. Estimate the 6 month intracranial progression rate and 6 month overall survival rate in patients with limited brain metastases from malignant melanoma undergoing whole brain radiotherapy followed by stereotactic radiosurgery boost. II. Evaluate the qualitative and quantitative toxic effects of this regimen in these patients.

    OUTLINE: Patients undergo whole brain radiotherapy 5 days a week for 3 weeks, followed 3-5 weeks later by stereotactic radiosurgery. Patients are followed every 3 months until death.

    PROJECTED ACCRUAL: A total of 60 patients will be accrued for this study within 2 years.

    86 locations

    United States (86)
    • MBCCOP - Gulf Coast
      Mobile, Alabama, United States, 36652
    • CCOP - Greater Phoenix
      Phoenix, Arizona, United States, 85006-2726
    • Veterans Affairs Medical Center - Phoenix (Hayden)
      Phoenix, Arizona, United States, 85012
    • Veterans Affairs Medical Center - Tucson
      Tucson, Arizona, United States, 85723
    • Arizona Cancer Center
      Tucson, Arizona, United States, 85724
    • University of Arkansas for Medical Sciences
      Little Rock, Arkansas, United States, 72205
    • Veterans Affairs Medical Center - Little Rock (McClellan)
      Little Rock, Arkansas, United States, 72205
    • Veterans Affairs Medical Center - Long Beach
      Long Beach, California, United States, 90822
    • USC/Norris Comprehensive Cancer Center
      Los Angeles, California, United States, 90033-0800
    • Jonsson Comprehensive Cancer Center, UCLA
      Los Angeles, California, United States, 90095-1781
    • Beckman Research Institute, City of Hope
      Los Angeles, California, United States, 91010
    • Veterans Affairs Outpatient Clinic - Martinez
      Martinez, California, United States, 94553
    • CCOP - Bay Area Tumor Institute
      Oakland, California, United States, 94609-3305
    • Chao Family Comprehensive Cancer Center
      Orange, California, United States, 92868
    • University of California Davis Medical Center
      Sacramento, California, United States, 95817
    • CCOP - Santa Rosa Memorial Hospital
      Santa Rosa, California, United States, 95403
    • David Grant Medical Center
      Travis Air Force Base, California, United States, 94535
    • Veterans Affairs Medical Center - Denver
      Denver, Colorado, United States, 80220
    • University of Colorado Cancer Center
      Denver, Colorado, United States, 80262
    • CCOP - Atlanta Regional
      Atlanta, Georgia, United States, 30342-1701
    • Dwight David Eisenhower Army Medical Center
      Fort Gordon, Georgia, United States, 30905-5650
    • Cancer Research Center of Hawaii
      Honolulu, Hawaii, United States, 96813
    • CCOP - Central Illinois
      Decatur, Illinois, United States, 62526
    • Veterans Affairs Medical Center - Hines (Hines Junior VA Hospital)
      Hines, Illinois, United States, 60141
    • Loyola University Medical Center
      Maywood, Illinois, United States, 60153
    • University of Kansas Medical Center
      Kansas City, Kansas, United States, 66160-7357
    • CCOP - Wichita
      Wichita, Kansas, United States, 67214-3882
    • Veterans Affairs Medical Center - Wichita
      Wichita, Kansas, United States, 67218
    • Veterans Affairs Medical Center - Lexington
      Lexington, Kentucky, United States, 40511-1093
    • MBCCOP - LSU Health Sciences Center
      New Orleans, Louisiana, United States, 70112
    • Tulane University School of Medicine
      New Orleans, Louisiana, United States, 70112
    • Veterans Affairs Medical Center - New Orleans
      New Orleans, Louisiana, United States, 70112
    • Louisiana State University Health Sciences Center - Shreveport
      Shreveport, Louisiana, United States, 71130-3932
    • Veterans Affairs Medical Center - Shreveport
      Shreveport, Louisiana, United States, 71130
    • Boston Medical Center
      Boston, Massachusetts, United States, 02118
    • Veterans Affairs Medical Center - Boston (Jamaica Plain)
      Jamaica Plain, Massachusetts, United States, 02130
    • Veterans Affairs Medical Center - Ann Arbor
      Ann Arbor, Michigan, United States, 48105
    • University of Michigan Comprehensive Cancer Center
      Ann Arbor, Michigan, United States, 48109-0752
    • Veterans Affairs Medical Center - Detroit
      Detroit, Michigan, United States, 48201-1932
    • Barbara Ann Karmanos Cancer Institute
      Detroit, Michigan, United States, 48201
    • Henry Ford Hospital
      Detroit, Michigan, United States, 48202
    • CCOP - Grand Rapids Clinical Oncology Program
      Grand Rapids, Michigan, United States, 49503
    • Providence Hospital - Southfield
      Southfield, Michigan, United States, 48075-9975
    • Veterans Affairs Medical Center - Biloxi
      Biloxi, Mississippi, United States, 39531-2410
    • University of Mississippi Medical Center
      Jackson, Mississippi, United States, 39216-4505
    • Veterans Affairs Medical Center - Jackson
      Jackson, Mississippi, United States, 39216
    • Keesler Medical Center - Keesler AFB
      Keesler AFB, Mississippi, United States, 39534-2576
    • Veterans Affairs Medical Center - Kansas City
      Kansas City, Missouri, United States, 64128
    • CCOP - Kansas City
      Kansas City, Missouri, United States, 64131
    • St. Louis University Health Sciences Center
      Saint Louis, Missouri, United States, 63110-0250
    • CCOP - St. Louis-Cape Girardeau
      Saint Louis, Missouri, United States, 63141
    • CCOP - Cancer Research for the Ozarks
      Springfield, Missouri, United States, 65807
    • CCOP - Montana Cancer Consortium
      Billings, Montana, United States, 59101
    • Veterans Affairs Medical Center - Albuquerque
      Albuquerque, New Mexico, United States, 87108-5138
    • MBCCOP - University of New Mexico HSC
      Albuquerque, New Mexico, United States, 87131
    • Herbert Irving Comprehensive Cancer Center
      New York, New York, United States, 10032
    • Barrett Cancer Center, The University Hospital
      Cincinnati, Ohio, United States, 45219
    • Veterans Affairs Medical Center - Cincinnati
      Cincinnati, Ohio, United States, 45220-2288
    • Cleveland Clinic Taussig Cancer Center
      Cleveland, Ohio, United States, 44195
    • CCOP - Columbus
      Columbus, Ohio, United States, 43206
    • Veterans Affairs Medical Center - Dayton
      Dayton, Ohio, United States, 45428
    • CCOP - Dayton
      Kettering, Ohio, United States, 45429
    • Oklahoma Medical Research Foundation
      Oklahoma City, Oklahoma, United States, 73104
    • Veterans Affairs Medical Center - Oklahoma City
      Oklahoma City, Oklahoma, United States, 73104
    • Oregon Cancer Institute at Oregon Health and Science University
      Portland, Oregon, United States, 97201-3098
    • Veterans Affairs Medical Center - Portland
      Portland, Oregon, United States, 97207
    • CCOP - Columbia River Program
      Portland, Oregon, United States, 97213
    • CCOP - Greenville
      Greenville, South Carolina, United States, 29615
    • CCOP - Upstate Carolina
      Spartanburg, South Carolina, United States, 29303
    • Simmons Cancer Center - Dallas
      Dallas, Texas, United States, 75235-9154
    • Brooke Army Medical Center
      Fort Sam Houston, Texas, United States, 78234
    • University of Texas Medical Branch
      Galveston, Texas, United States, 77555-0209
    • Texas Tech University Health Science Center
      Lubbock, Texas, United States, 79423
    • University of Texas Health Science Center at San Antonio
      San Antonio, Texas, United States, 78284-7811
    • Veterans Affairs Medical Center - San Antonio (Murphy)
      San Antonio, Texas, United States, 78284
    • Veterans Affairs Medical Center - Temple
      Temple, Texas, United States, 76504
    • CCOP - Scott and White Hospital
      Temple, Texas, United States, 76508
    • Huntsman Cancer Institute
      Salt Lake City, Utah, United States, 84132
    • Veterans Affairs Medical Center - Salt Lake City
      Salt Lake City, Utah, United States, 84148
    • CCOP - Virginia Mason Research Center
      Seattle, Washington, United States, 98101
    • Swedish Cancer Institute
      Seattle, Washington, United States, 98104
    • Veterans Affairs Medical Center - Seattle
      Seattle, Washington, United States, 98108
    • University of Washington Medical Center
      Seattle, Washington, United States, 98195-6043
    • University of Washington
      Seattle, Washington, United States, 98195
    • CCOP - Northwest
      Tacoma, Washington, United States, 98405-0986
    • MultiCare Radiation Oncology
      Tacoma, Washington, United States, 98405
    Status:
    terminated
    Type:
    Interventional
    Phase:
    Start:
    30 June, 1999
    Updated:
    29 January, 2013
    Participants:
    2
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