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Evaluation of the Combination of Docetaxel (Taxotere)/ Carboplatin in Patients With Metastatic or Recurrent Squamous Cell Carcinoma of the Head and Neck (SCCHN) (NCT00003908)

National Cancer Institute (NCI)
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of docetaxel plus carboplatin in treating patients who have metastatic or recurrent head and neck cancer.
  • Drug: carboplatin
    • Drug: docetaxel
      Ages eligible for Study
      18 Years and older
      Genders eligible for Study
      All
      Accepts Healthy Volunteers
      No
      OBJECTIVES: I. Assess the survival of patients with metastatic or recurrent squamous cell carcinoma of the head and neck receiving docetaxel and carboplatin. II. Assess time to treatment failure and response rate (unconfirmed and confirmed complete and partial response) in this patient population. III. Evaluate the toxicities of this regimen in this patient population.

      OUTLINE: Patients receive docetaxel IV over 1 hour immediately followed by carboplatin IV over 30 minutes on day 1. Courses repeat every 3 weeks in the absence of unacceptable toxicity or disease progression. Patients are followed every 3 months for 1 year, every 6 months for 2 years, then annually thereafter until death.

      PROJECTED ACCRUAL: A total of 62 patients will be accrued for this study over 18 months.

      85 locations

      United States (85)
      • MBCCOP - University of South Alabama
        Mobile, Alabama, United States, 36688
      • CCOP - Greater Phoenix
        Phoenix, Arizona, United States, 85006-2726
      • Veterans Affairs Medical Center - Phoenix (Hayden)
        Phoenix, Arizona, United States, 85012
      • Veterans Affairs Medical Center - Tucson
        Tucson, Arizona, United States, 85723
      • Arizona Cancer Center
        Tucson, Arizona, United States, 85724
      • University of Arkansas for Medical Sciences
        Little Rock, Arkansas, United States, 72205
      • Veterans Affairs Medical Center - Little Rock (McClellan)
        Little Rock, Arkansas, United States, 72205
      • Veterans Affairs Medical Center - Long Beach
        Long Beach, California, United States, 90822
      • USC/Norris Comprehensive Cancer Center
        Los Angeles, California, United States, 90033-0800
      • Jonsson Comprehensive Cancer Center, UCLA
        Los Angeles, California, United States, 90095-1781
      • Beckman Research Institute, City of Hope
        Los Angeles, California, United States, 91010
      • Veterans Affairs Outpatient Clinic - Martinez
        Martinez, California, United States, 94553
      • CCOP - Bay Area Tumor Institute
        Oakland, California, United States, 94609-3305
      • Chao Family Comprehensive Cancer Center
        Orange, California, United States, 92868
      • University of California Davis Medical Center
        Sacramento, California, United States, 95817
      • CCOP - Santa Rosa Memorial Hospital
        Santa Rosa, California, United States, 95403
      • David Grant Medical Center
        Travis Air Force Base, California, United States, 94535
      • Veterans Affairs Medical Center - Denver
        Denver, Colorado, United States, 80220
      • University of Colorado Cancer Center
        Denver, Colorado, United States, 80262
      • CCOP - Atlanta Regional
        Atlanta, Georgia, United States, 30342-1701
      • Dwight David Eisenhower Army Medical Center
        Fort Gordon, Georgia, United States, 30905-5650
      • Cancer Research Center of Hawaii
        Honolulu, Hawaii, United States, 96813
      • CCOP - Central Illinois
        Decatur, Illinois, United States, 62526
      • Veterans Affairs Medical Center - Hines (Hines Junior VA Hospital)
        Hines, Illinois, United States, 60141
      • Loyola University Medical Center
        Maywood, Illinois, United States, 60153
      • University of Kansas Medical Center
        Kansas City, Kansas, United States, 66160-7357
      • CCOP - Wichita
        Wichita, Kansas, United States, 67214-3882
      • Veterans Affairs Medical Center - Wichita
        Wichita, Kansas, United States, 67218
      • Veterans Affairs Medical Center - Lexington
        Lexington, Kentucky, United States, 40511-1093
      • Albert B. Chandler Medical Center, University of Kentucky
        Lexington, Kentucky, United States, 40536-0084
      • MBCCOP - LSU Medical Center
        New Orleans, Louisiana, United States, 70112
      • Tulane University School of Medicine
        New Orleans, Louisiana, United States, 70112
      • Veterans Affairs Medical Center - New Orleans
        New Orleans, Louisiana, United States, 70112
      • Louisiana State University Health Sciences Center - Shreveport
        Shreveport, Louisiana, United States, 71130-3932
      • Veterans Affairs Medical Center - Shreveport
        Shreveport, Louisiana, United States, 71130
      • Boston Medical Center
        Boston, Massachusetts, United States, 02118
      • Veterans Affairs Medical Center - Boston (Jamaica Plain)
        Jamaica Plain, Massachusetts, United States, 02130
      • Veterans Affairs Medical Center - Ann Arbor
        Ann Arbor, Michigan, United States, 48105
      • University of Michigan Comprehensive Cancer Center
        Ann Arbor, Michigan, United States, 48109-0752
      • Veterans Affairs Medical Center - Detroit
        Detroit, Michigan, United States, 48201-1932
      • Barbara Ann Karmanos Cancer Institute
        Detroit, Michigan, United States, 48201
      • Henry Ford Hospital
        Detroit, Michigan, United States, 48202
      • CCOP - Grand Rapids Clinical Oncology Program
        Grand Rapids, Michigan, United States, 49503
      • Providence Hospital - Southfield
        Southfield, Michigan, United States, 48075-9975
      • Veterans Affairs Medical Center - Biloxi
        Biloxi, Mississippi, United States, 39531-2410
      • University of Mississippi Medical Center
        Jackson, Mississippi, United States, 39216-4505
      • Veterans Affairs Medical Center - Jackson
        Jackson, Mississippi, United States, 39216
      • Keesler Medical Center - Keesler AFB
        Keesler AFB, Mississippi, United States, 39534-2576
      • Veterans Affairs Medical Center - Kansas City
        Kansas City, Missouri, United States, 64128
      • CCOP - Kansas City
        Kansas City, Missouri, United States, 64131
      • St. Louis University Health Sciences Center
        Saint Louis, Missouri, United States, 63110-0250
      • CCOP - St. Louis-Cape Girardeau
        Saint Louis, Missouri, United States, 63141
      • CCOP - Cancer Research for the Ozarks
        Springfield, Missouri, United States, 65807
      • CCOP - Montana Cancer Consortium
        Billings, Montana, United States, 59101
      • Veterans Affairs Medical Center - Albuquerque
        Albuquerque, New Mexico, United States, 87108-5138
      • MBCCOP - University of New Mexico HSC
        Albuquerque, New Mexico, United States, 87131
      • Herbert Irving Comprehensive Cancer Center
        New York, New York, United States, 10032
      • Barrett Cancer Center, The University Hospital
        Cincinnati, Ohio, United States, 45219
      • Veterans Affairs Medical Center - Cincinnati
        Cincinnati, Ohio, United States, 45220-2288
      • Cleveland Clinic Cancer Center
        Cleveland, Ohio, United States, 44195
      • CCOP - Columbus
        Columbus, Ohio, United States, 43206
      • Cancer Services
        Columbus, Ohio, United States, 43214
      • Veterans Affairs Medical Center - Dayton
        Dayton, Ohio, United States, 45428
      • CCOP - Dayton
        Kettering, Ohio, United States, 45429
      • Oklahoma Medical Research Foundation
        Oklahoma City, Oklahoma, United States, 73104
      • Veterans Affairs Medical Center - Oklahoma City
        Oklahoma City, Oklahoma, United States, 73104
      • Oregon Cancer Center at Oregon Health Sciences University
        Portland, Oregon, United States, 97201-3098
      • Veterans Affairs Medical Center - Portland
        Portland, Oregon, United States, 97207
      • CCOP - Columbia River Program
        Portland, Oregon, United States, 97213
      • CCOP - Greenville
        Greenville, South Carolina, United States, 29615
      • CCOP - Upstate Carolina
        Spartanburg, South Carolina, United States, 29303
      • Simmons Cancer Center - Dallas
        Dallas, Texas, United States, 75235-9154
      • Brooke Army Medical Center
        Fort Sam Houston, Texas, United States, 78234
      • University of Texas Medical Branch
        Galveston, Texas, United States, 77555-1329
      • Texas Tech University Health Science Center
        Lubbock, Texas, United States, 79423
      • University of Texas Health Science Center at San Antonio
        San Antonio, Texas, United States, 78284-7811
      • Veterans Affairs Medical Center - San Antonio (Murphy)
        San Antonio, Texas, United States, 78284
      • Veterans Affairs Medical Center - Temple
        Temple, Texas, United States, 76504
      • CCOP - Scott and White Hospital
        Temple, Texas, United States, 76508
      • Huntsman Cancer Institute
        Salt Lake City, Utah, United States, 84132
      • Veterans Affairs Medical Center - Salt Lake City
        Salt Lake City, Utah, United States, 84148
      • CCOP - Virginia Mason Research Center
        Seattle, Washington, United States, 98101
      • Swedish Cancer Institute
        Seattle, Washington, United States, 98104
      • Veterans Affairs Medical Center - Seattle
        Seattle, Washington, United States, 98108
      • CCOP - Northwest
        Tacoma, Washington, United States, 98405-0986
      Status:
      completed
      Type:
      Interventional
      Phase:
      Start:
      31 October, 1999
      Updated:
      16 April, 2013
      Participants:
      68
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