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Molecular Genetic Features of Acute Leukemia (NCT00003861)

National Cancer Institute (NCI)
This research trial studies molecular genetic features in blood and tissue samples from patients with newly diagnosed acute lymphoblastic leukemia or acute promyelocytic leukemia. Studying samples of blood and tissue from patients with acute lymphoblastic leukemia or acute promyelocytic leukemia in the laboratory may help doctors identify and learn more about biomarkers related to cancer.
  • Other: laboratory biomarker analysis
    Ages eligible for Study
    all
    Genders eligible for Study
    All
    Accepts Healthy Volunteers
    No
    Objectives:

    1. To perform quantitative PCR using known leukemia specific markers in diagnostic bone marrow specimens of patients with newly diagnosed APL and ALL and to correlative pre-treatment copy number with other biologic and molecular features, clinical response, and treatment outcome.

    2. To evaluate the expression of novel genes or microRNAs implicated in disease pathogenesis and treatment response in pretreatment blood and bone marrow specimens of patients with APL and ALL and to correlate expression level with other biological features and treatment outcome.

    3. To evaluate the clinical significance of sequential quantitative MRD measurements using real-time quantitative PCR and/or flow cytometry during and following treatment of ALL and APL and correlate these findings with efficacy of novel treatment approaches and with other biological and clinical prognostic features.

    4. To compare measurement of MRD in blood with bone marrow specimens in sequential remission specimens of patients receiving treatment on ALL and APL treatment trials.

    51 locations

    United States (51)
    • Naval Medical Center - San Diego
      San Diego, California, United States, 92134
    • UCSF Helen Diller Family Comprehensive Cancer Center
      San Francisco, California, United States, 94115
    • Tunnell Cancer Center at Beebe Medical Center
      Lewes, Delaware, United States, 19958
    • CCOP - Christiana Care Health Services
      Newark, Delaware, United States, 19713
    • Florida Hospital Cancer Institute at Florida Hospital Orlando
      Orlando, Florida, United States, 32803-1273
    • University of Illinois Cancer Center
      Chicago, Illinois, United States, 60612-7243
    • University of Chicago Cancer Research Center
      Chicago, Illinois, United States, 60637-1470
    • Holden Comprehensive Cancer Center at University of Iowa
      Iowa City, Iowa, United States, 52242-1002
    • Harold Alfond Center for Cancer Care
      Augusta, Maine, United States, 04330
    • CancerCare of Maine at Eastern Maine Medical Center
      Bangor, Maine, United States, 04401
    • Maine Center for Cancer Medicine and Blood Disorders - Scarborough
      Scarborough, Maine, United States, 04074
    • Greenebaum Cancer Center at University of Maryland Medical Center
      Baltimore, Maryland, United States, 21201
    • Union Hospital of Cecil County
      Elkton MD, Maryland, United States, 21921
    • Massachusetts General Hospital
      Boston, Massachusetts, United States, 02114
    • Dana-Farber/Brigham and Women's Cancer Center
      Boston, Massachusetts, United States, 02115
    • Dana-Farber/Harvard Cancer Center at Dana-Farber Cancer Institute
      Boston, Massachusetts, United States, 02115
    • Masonic Cancer Center at University of Minnesota
      Minneapolis, Minnesota, United States, 55455
    • Ellis Fischel Cancer Center at University of Missouri - Columbia
      Columbia, Missouri, United States, 65203
    • Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis
      Saint Louis, Missouri, United States, 63110
    • University Medical Center of Southern Nevada
      Las Vegas, Nevada, United States, 89102
    • CCOP - Nevada Cancer Research Foundation
      Las Vegas, Nevada, United States, 89106
    • Cancer Institute of New Jersey at Cooper - Voorhees
      Voorhees, New Jersey, United States, 08043
    • Roswell Park Cancer Institute
      Buffalo, New York, United States, 14263-0001
    • CCOP - Hematology-Oncology Associates of Central New York
      East Syracuse, New York, United States, 13057
    • Queens Cancer Center of Queens Hospital
      Jamaica, New York, United States, 11432
    • Monter Cancer Center of the North Shore-LIJ Health System
      Lake Success, New York, United States, 11042
    • CCOP - North Shore University Hospital
      Manhasset, New York, United States, 11030
    • Don Monti Comprehensive Cancer Center at North Shore University Hospital
      Manhasset, New York, United States, 11030
    • Long Island Jewish Medical Center
      New Hyde Park, New York, United States, 11040
    • New York Weill Cornell Cancer Center at Cornell University
      New York, New York, United States, 10021
    • Mount Sinai Medical Center
      New York, New York, United States, 10029
    • SUNY Upstate Medical University Hospital
      Syracuse, New York, United States, 13210
    • Veterans Affairs Medical Center - Syracuse
      Syracuse, New York, United States, 13210
    • Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill
      Chapel Hill, North Carolina, United States, 27599-7295
    • Duke Cancer Institute
      Durham, North Carolina, United States, 27710
    • Wayne Memorial Hospital, Incorporated
      Goldsboro, North Carolina, United States, 27534
    • Leo W. Jenkins Cancer Center at ECU Medical School
      Greenville, North Carolina, United States, 27834
    • Kinston Medical Specialists
      Kinston, North Carolina, United States, 28501
    • Wake Forest University Comprehensive Cancer Center
      Winston-Salem, North Carolina, United States, 27157-1096
    • Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center
      Columbus, Ohio, United States, 43210-1240
    • Western Pennsylvania Cancer Institute at Western Pennsylvania Hospital
      Pittsburgh, Pennsylvania, United States, 15224-1791
    • Rhode Island Hospital Comprehensive Cancer Center
      Providence, Rhode Island, United States, 02903
    • Miriam Hospital
      Providence, Rhode Island, United States, 02906
    • Cancer Centers of the Carolinas - Faris Road
      Greenville, South Carolina, United States, 29605
    • Cancer Centers of the Carolinas - Grove Commons
      Greenville, South Carolina, United States, 29605
    • Greenville Hospital Cancer Center
      Greenville, South Carolina, United States, 29605
    • CCOP - Greenville
      Greenville, South Carolina, United States, 29615
    • Cancer Centers of the Carolinas - Greer Medical Oncology
      Greer, South Carolina, United States, 29650
    • Cancer Centers of the Carolinas - Seneca
      Seneca, South Carolina, United States, 29672
    • Cancer Centers of the Carolinas - Spartanburg
      Spartanburg, South Carolina, United States, 29307
    • Virginia Commonwealth University Massey Cancer Center
      Richmond, Virginia, United States, 23298-0037
    Status:
    active not recruiting
    Type:
    Observational
    Phase:
    -
    Start:
    31 March, 1999
    Updated:
    03 May, 2016
    Participants:
    840
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