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Tumor Replication Error (RER) Status and Outcome in a Colon Cancer Adjuvant Chemotherapy Trial (NCT00003571)

National Cancer Institute (NCI)
RATIONALE: Analyzing the structure of genes found in a person's cancer cells may help doctors improve methods of treating patients with colon cancer. PURPOSE: Clinical trial to study the genes of patients treated with chemotherapy for colon cancer.
  • Genetic: mutation analysis
    • Genetic: tumor replication error analysis
      Ages eligible for Study
      all
      Genders eligible for Study
      All
      Accepts Healthy Volunteers
      No
      OBJECTIVES:

      - Determine the relationship between disease free survival, overall survival, and tumor replication error status for patients who have received adjuvant chemotherapy for colon cancer on CALGB protocol 8896.

      - Determine the prognostic and predictive values for response to this therapy in these patients.

      44 locations

      United States (44)
      • Veterans Affairs Medical Center - Birmingham
        Birmingham, Alabama, United States, 35233-1996
      • University of California San Diego Cancer Center
        La Jolla, California, United States, 92093-0658
      • Veterans Affairs Medical Center - San Francisco
        San Francisco, California, United States, 94121
      • UCSF Cancer Center and Cancer Research Institute
        San Francisco, California, United States, 94143-0128
      • CCOP - Christiana Care Health Services
        Wilmington, Delaware, United States, 19899
      • Lombardi Cancer Center
        Washington, District of Columbia, United States, 20007
      • Walter Reed Army Medical Center
        Washington, District of Columbia, United States, 20307-5000
      • CCOP - Mount Sinai Medical Center
        Miami Beach, Florida, United States, 33140
      • Veterans Affairs Medical Center - Chicago (Westside Hospital)
        Chicago, Illinois, United States, 60612
      • University of Chicago Cancer Research Center
        Chicago, Illinois, United States, 60637-1470
      • Holden Comprehensive Cancer Center at The University of Iowa
        Iowa City, Iowa, United States, 52242-1009
      • Veterans Affairs Medical Center - Togus
        Togus, Maine, United States, 04330
      • Marlene & Stewart Greenebaum Cancer Center, University of Maryland
        Baltimore, Maryland, United States, 21201
      • Dana-Farber Cancer Institute
        Boston, Massachusetts, United States, 02115
      • University of Massachusetts Memorial Medical Center
        Worcester, Massachusetts, United States, 01655
      • Veterans Affairs Medical Center - Minneapolis
        Minneapolis, Minnesota, United States, 55417
      • Veterans Affairs Medical Center - Columbia (Truman Memorial)
        Columbia, Missouri, United States, 65201
      • Ellis Fischel Cancer Center - Columbia
        Columbia, Missouri, United States, 65203
      • Barnes-Jewish Hospital
        Saint Louis, Missouri, United States, 63110
      • University of Nebraska Medical Center
        Omaha, Nebraska, United States, 68198-3330
      • CCOP - Southern Nevada Cancer Research Foundation
        Las Vegas, Nevada, United States, 89106
      • Norris Cotton Cancer Center
        Lebanon, New Hampshire, United States, 03756-0002
      • Veterans Affairs Medical Center - Buffalo
        Buffalo, New York, United States, 14215
      • Roswell Park Cancer Institute
        Buffalo, New York, United States, 14263-0001
      • CCOP - North Shore University Hospital
        Manhasset, New York, United States, 11030
      • Schneider Children's Hospital at North Shore
        Manhasset, New York, United States, 11030
      • Memorial Sloan-Kettering Cancer Center
        New York, New York, United States, 10021
      • New York Presbyterian Hospital - Cornell Campus
        New York, New York, United States, 10021
      • Mount Sinai Medical Center, NY
        New York, New York, United States, 10029
      • State University of New York - Upstate Medical University
        Syracuse, New York, United States, 13210
      • Veterans Affairs Medical Center - Syracuse
        Syracuse, New York, United States, 13210
      • CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C.
        Syracuse, New York, United States, 13217
      • Lineberger Comprehensive Cancer Center, UNC
        Chapel Hill, North Carolina, United States, 27599-7295
      • Veterans Affairs Medical Center - Durham
        Durham, North Carolina, United States, 27705
      • Duke Comprehensive Cancer Center
        Durham, North Carolina, United States, 27710
      • CCOP - Southeast Cancer Control Consortium
        Winston-Salem, North Carolina, United States, 27104-4241
      • Comprehensive Cancer Center at Wake Forest University
        Winston-Salem, North Carolina, United States, 27157-1082
      • Arthur G. James Cancer Hospital - Ohio State University
        Columbus, Ohio, United States, 43210-1240
      • Rhode Island Hospital
        Providence, Rhode Island, United States, 02903
      • University of Tennessee, Memphis Cancer Center
        Memphis, Tennessee, United States, 38103
      • Veterans Affairs Medical Center - Memphis
        Memphis, Tennessee, United States, 38104
      • Veterans Affairs Medical Center - White River Junction
        White River Junction, Vermont, United States, 05009
      • Veterans Affairs Medical Center - Richmond
        Richmond, Virginia, United States, 23249
      • MBCCOP - Massey Cancer Center
        Richmond, Virginia, United States, 23298-0037
      Status:
      completed
      Type:
      Observational
      Phase:
      -
      Start:
      31 July, 1998
      Updated:
      30 June, 2016
      Participants:
      300
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